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Lamivudine(Epivir) generic is a potent nucleoside analog reverse transcriptase inhibitor (nRTI), prescribed for HIV/AIDS, and hepatitis B either alone or with other medication View images of Epivir a gray diamond tablet, film coated about 17 mm in size, imprinted with GX and EJ7. Common Epivir side effects may include: nausea, diarrhea; headache; fever, tiredness, general ill feeling; ear infection - ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child; or. Lamivudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs) Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. [1] It is also used to treat chronic hepatitis B when other options are not possible. 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